Organoids are 3D cell culture systems that mimic some of the structural and functional
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …

The cell–cell connections in adherens junctions (AJs) are mediated by transmembrane
receptors, type I cadherins (referred to here as cadherins). These cadherin-based …

A common theme in the self-organization of multicellular tissues is the use of cell-cell
signaling networks to induce morphological changes. We used the modular synNotch …

Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show
that CAFs exert a physical force on cancer cells that enables their collective invasion. Force …

The ability of cells to organize into multicellular structures in precise patterns requires that
they" recognize" one another with high specificity. We discuss recent progress in …

Desmosomes are intercellular adhesive junctions that impart strength to vertebrate tissues.
Their dense, ordered intercellular attachments are formed by desmogleins (Dsgs) and …

The majority of cancer-associated deaths are related to secondary tumor formation. This
multistep process involves the migration of cancer cells to anatomically distant organs …

The development of ESR methods that measure long‐range distance distributions has
advanced biophysical research. However, the spin labels commonly employed are highly …

The integrity of living tissues is maintained by adhesion domains of trans-bonds formed
between cadherin proteins residing on opposing membranes of neighbouring cells. These …

Clustered protocadherin proteins (α-, β-, and γ-Pcdhs) provide a high level of cell-surface
diversity to individual vertebrate neurons, engaging in highly specific homophilic interactions …