Antibodies play an essential role in host defence against pathogens by recognizing
microorganisms or infected cells. Although preventing pathogen entry is one potential …

The cellular uptake, intracellular processing, and presentation of foreign antigen are crucial
processes for eliciting an effective adaptive host response to the majority of pathogens. The …

Antigen cross-presentation is an adaptation of the cellular process of loading MHC-I
molecules with endogenous peptides during their biosynthesis within the endoplasmic …

Fc γ receptors (FcγR) expressed on the surface of human leukocytes bind clusters of
immunoglobulin G (IgG) to induce a variety of responses. Many therapeutic antibodies and …

FcγRIIb is the only inhibitory Fc receptor and controls many aspects of immune and
inflammatory responses. The observation 19 years ago that Fc γ RIIb−/− mice generated by …

In recent years, therapeutic monoclonal antibodies have made impressive progress,
providing great benefit by successfully treating malignant and chronic inflammatory …

Dendritic cells (DCs) are efficient antigen-presenting cells equipped with various cell surface
receptors for the direct or indirect recognition of pathogenic microorganisms. Interestingly …

Recent advances in the development of therapeutic antibodies (Abs) have greatly improved
the treatment of otherwise drug-resistant cancers and autoimmune diseases. Antibody …

Clinical and experimental preparations of IgG/soluble antigen complexes, as well as those
formed following antibody therapy in vivo, are multifaceted immune regulators. These …

Summary MHC class I (MHC‐I) molecules are the centerpieces of cross‐presentation. They
are loaded with peptides derived from exogenous sources and displayed on the plasma …