Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Chromosomal instability (CIN) is a hallmark of many tumours and correlates with the
presence of extra centrosomes,,,. However, a direct mechanistic link between extra …

Centrosomes are microtubule-organizing centres of animal cells. They influence the
morphology of the microtubule cytoskeleton, function as the base for the primary cilium and …

The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart
from its role in mediating sister chromatid cohesion, it is also important for DNA double …

The distal appendages (DAPs) of centrioles have been proposed to anchor cilia to the
plasma membrane, but their molecular composition, assembly, and exact function in …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Centrioles are barrel-shaped structures that are essential for the formation of centrosomes,
cilia, and flagella. Here we review recent advances in our understanding of the function and …

We show that overexpression of Polo-like kinase 4 (Plk4) in human cells induces
centrosome amplification through the simultaneous generation of multiple procentrioles …

Asymmetric divisions of radial glia progenitors produce self-renewing radial glia and
differentiating cells simultaneously in the ventricular zone (VZ) of the developing neocortex …