Brain plasticity is the potential of the nervous system to reshape itself during ontogeny,
learning or following injuries. The first part of this article reviews the pathophysiological …

Simple Summary Surgery is the primary treatment for chordoma. However, residual or
recurrent chordoma presents a significant problem for clinicians. The aim of this work is to …

Object The role of surgery and adjuvant radiation therapy for cranial base chordomas is not
well established. This meta-analysis measures the relationship of complete resection and …

Object Chordomas are rare malignant neoplasms arising predominantly at the sacrum and
skull base. They are uniformly lethal unless treated with aggressive resection and proton …

Object The goal of this study was to report on the surgical management of skull base
chordomas and to evaluate both the short-and long-term treatment outcomes. Methods The …

PURPOSE: The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase
is overexpressed in various tumors and has been linked to poor prognosis. Its role as proto …

Previous studies of chordoma have focused on either surgery, radiotherapy, or particular
tumor locations. This paper reviewed the outcomes of surgery and proton radiotherapy with …

OBJECTIVE Skull base chordoma is relatively rare, and a limited number of reports have
been published regarding its clinical features. Moreover, the factors associated with extent of …

Little data exists comparing endoscopic endonasal approaches to pathology of the anterior
skull base with more traditional transcranial and transsphenoidal microscopic approaches …

The molecular events in chordoma pathogenesis have not been fully delineated, particularly
with respect to copy number changes. Understanding copy number alterations in chordoma …