In the open metabolic system, redox-related signaling requires continuous monitoring and
fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a …

The etiology of hypertension involves complex interactions among genetic, environmental,
and pathophysiologic factors that influence many regulatory systems. Hypertension is …

Serum uric acid (SUA) is significantly elevated in obesity, gout, type 2 diabetes mellitus, and
the metabolic syndrome and appears to contribute to the renal, cardiovascular and …

Kynurenine pathway is the main route of tryptophan metabolism and produces several
metabolites with various biologic properties. It has been uncovered that several …

For the treatment of systemic hypertension, pharmacological intervention in nitric oxide-
cyclic guanosine monophosphate signaling is a well-explored but unexploited option. In this …

Cardiovascular disease remains the leading cause of death worldwide despite major
advances in technology and treatment, with coronary heart disease (CHD) being a key …

Hypertension stands as a pervasive global health challenge, contributing significantly to
mortality rates worldwide. Various factors, including lifestyle choices and dietary habits …

Despite the overwhelming number of sports supplements on the market, only seven are
currently recognized as effective. Biological functions are largely regulated through redox …

Abstract S-nitrosothiols (SNO), dinitrosyl iron complexes (DNIC), and nitroglycerine (NTG)
dilate vessels via activation of soluble guanylyl cyclase (sGC) in vascular smooth muscle …

Mitochondria play fundamental role in maintaining cellular metabolic homeostasis, and
metabolic disorders including type 2 diabetes (T2D) have been associated with …