Plasmodium falciparum Proteases as new drug targets with special focus on Metalloproteases
PJ Mahanta, K Lhouvum - Molecular and Biochemical Parasitology, 2024 - Elsevier
Malaria poses a significant global health threat particularly due to the prevalence of
Plasmodium falciparum infection. With the emergence of parasite resistance to existing …
Plasmodium falciparum infection. With the emergence of parasite resistance to existing …
General strategies for using amino acid sequence data to guide biochemical investigation of protein function
EN Kennedy, CA Foster, SA Barr… - Biochemical Society …, 2022 - portlandpress.com
The rapid increase of '-omics' data warrants the reconsideration of experimental strategies to
investigate general protein function. Studying individual members of a protein family is likely …
investigate general protein function. Studying individual members of a protein family is likely …
Discovery of potent and selective inhibitors of the Escherichia coli M1-aminopeptidase via multicomponent solid-phase synthesis of tetrazole-peptidomimetics
Y Méndez, G De Armas, I Pérez, T Rojas… - European Journal of …, 2019 - Elsevier
The Escherichia coli neutral M1-aminopeptidase (ePepN) is a novel target identified for the
development of antimicrobials. Here we describe a solid-phase multicomponent approach …
development of antimicrobials. Here we describe a solid-phase multicomponent approach …
[HTML][HTML] Mammalian glutamyl aminopeptidase genes (ENPEP) and proteins: Comparative studies of a major contributor to arterial hypertension
RS Holmes, KD Spradling-Reeves… - Journal of data mining in …, 2017 - ncbi.nlm.nih.gov
Glutamyl aminopeptidase (ENPEP) is a member of the M1 family of endopeptidases which
are mammalian type II integral membrane zinc-containing endopeptidases. ENPEP is …
are mammalian type II integral membrane zinc-containing endopeptidases. ENPEP is …
Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo
L Bounaadja, M Schmitt, S Albrecht, E Mouray… - Malaria Journal, 2017 - Springer
Background Plasmodium falciparum M1 family aminopeptidase is currently considered as a
promising target for anti-malarial chemotherapy. Several series of inhibitors developed by …
promising target for anti-malarial chemotherapy. Several series of inhibitors developed by …
Next Generation Sequencing Identifies Five Major Classes of Potentially Therapeutic Enzymes Secreted by Lucilia sericata Medical Maggots
Lucilia sericata larvae are used as an alternative treatment for recalcitrant and chronic
wounds. Their excretions/secretions contain molecules that facilitate tissue debridement …
wounds. Their excretions/secretions contain molecules that facilitate tissue debridement …
Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N
Actinonin is a pseudotripeptide that displays a high affinity towards metalloproteases
including peptide deformylases (PDFs) and M1 family aminopeptidases. PDF and M1 family …
including peptide deformylases (PDFs) and M1 family aminopeptidases. PDF and M1 family …
[HTML][HTML] Metallopeptidases of Toxoplasma gondii: in silico identification and gene expression
S Escotte-Binet, A Huguenin, D Aubert, AP Martin… - Parasite, 2018 - ncbi.nlm.nih.gov
Metallopeptidases are a family of proteins with domains that remain highly conserved
throughout evolution. These hydrolases require divalent metal cation (s) to activate the water …
throughout evolution. These hydrolases require divalent metal cation (s) to activate the water …
Puromycin, a selective inhibitor of PSA acts as a substrate for other M1 family aminopeptidases: Biochemical and structural basis
Puromycin sensitive aminopeptidase (PSA or NPEPPS) is a M1 class aminopeptidase is
selectively inhibited by the natural product puromycin, an aminonucleoside antibiotic …
selectively inhibited by the natural product puromycin, an aminonucleoside antibiotic …
Bacterial metalo-aminopeptidases as targets in human infectious diseases
J González-Bacerio, AC Varela, ME Aguado… - Current Drug …, 2022 - ingentaconnect.com
Background: Human infectious diseases caused by bacteria are a worldwide health problem
due to the increased resistance of these microorganisms to conventional antibiotics. For this …
due to the increased resistance of these microorganisms to conventional antibiotics. For this …