Dentate gyrus of the hippocampus continuously gives rise to new neurons, namely, adult-
born granule cells, which contribute to conferring plasticity to the mature brain throughout …

Background: Chronic pain is a significant clinical problem and a very complex
pathophysiological phenomenon. There is growing evidence that targeting the …

Endocannabinoid (eCB) signaling is markedly decreased in the hippocampus (Hip) of aged
mice, and the genetic deletion of the cannabinoid receptor type 1 (CB1) leads to an early …

Critical period plasticity at adult-born neuron synapses is widely believed to contribute to the
learning and memory functions of the hippocampus. Experience regulates circuit integration …

The hippocampus is vulnerable to traumatic brain injury (TBI), and hippocampal damage is
associated with cognitive deficits that are often the hallmark of TBI. Recent studies have …

High frequency burst firing is critical in summation of back-propagating action potentials
(APs) in dendrites, which may greatly depolarize dendritic membrane potential. The …

Background/Objectives: Omega-3 long-chain polyunsaturated fatty acids (PUFAs) support
brain cell membrane integrity and help mitigate synaptic plasticity deficits. The …

Profound deficits in hippocampal synaptic plasticity after traumatic brain injury and seizure is
ameliorated by prophylactic levetiracetam - PMC Back to Top Skip to main content NIH NLM …

Hebbian plasticity describes a basic mechanism for synaptic plasticity whereby synaptic
weights evolve depending on the relative timing of paired activity of the pre-and postsynaptic …