Harnessing multimodal data integration to advance precision oncology
Advances in quantitative biomarker development have accelerated new forms of data-driven
insights for patients with cancer. However, most approaches are limited to a single mode of …
insights for patients with cancer. However, most approaches are limited to a single mode of …
Artificial intelligence in cancer imaging: clinical challenges and applications
Judgement, as one of the core tenets of medicine, relies upon the integration of multilayered
data with nuanced decision making. Cancer offers a unique context for medical decisions …
data with nuanced decision making. Cancer offers a unique context for medical decisions …
Single-cell spatial immune landscapes of primary and metastatic brain tumours
E Karimi, MW Yu, SM Maritan, LJM Perus… - Nature, 2023 - nature.com
Single-cell technologies have enabled the characterization of the tumour microenvironment
at unprecedented depth and have revealed vast cellular diversity among tumour cells and …
at unprecedented depth and have revealed vast cellular diversity among tumour cells and …
[HTML][HTML] Glioblastoma hijacks neuronal mechanisms for brain invasion
V Venkataramani, Y Yang, MC Schubert, E Reyhan… - Cell, 2022 - cell.com
Glioblastomas are incurable tumors infiltrating the brain. A subpopulation of glioblastoma
cells forms a functional and therapy-resistant tumor cell network interconnected by tumor …
cells forms a functional and therapy-resistant tumor cell network interconnected by tumor …
Cell type and gene expression deconvolution with BayesPrism enables Bayesian integrative analysis across bulk and single-cell RNA sequencing in oncology
Inferring single-cell compositions and their contributions to global gene expression changes
from bulk RNA sequencing (RNA-seq) datasets is a major challenge in oncology. Here we …
from bulk RNA sequencing (RNA-seq) datasets is a major challenge in oncology. Here we …
The rsna-asnr-miccai brats 2021 benchmark on brain tumor segmentation and radiogenomic classification
The BraTS 2021 challenge celebrates its 10th anniversary and is jointly organized by the
Radiological Society of North America (RSNA), the American Society of Neuroradiology …
Radiological Society of North America (RSNA), the American Society of Neuroradiology …
Glioma progression is shaped by genetic evolution and microenvironment interactions
The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify
treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …
treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …
Transcriptome analysis reveals tumor microenvironment changes in glioblastoma
Y Hoogstrate, K Draaisma, SA Ghisai, L van Hijfte… - Cancer Cell, 2023 - cell.com
A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be
crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq)(n= 322 test …
crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq)(n= 322 test …
Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression
Glioblastoma (GBM), a highly lethal brain cancer, is notorious for immunosuppression, but
the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor …
the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor …
Interrogation of the microenvironmental landscape in brain tumors reveals disease-specific alterations of immune cells
Brain malignancies encompass a range of primary and metastatic cancers, including low-
grade and high-grade gliomas and brain metastases (BrMs) originating from diverse …
grade and high-grade gliomas and brain metastases (BrMs) originating from diverse …