Reciprocal interactions between epithelial and mesenchymal tissues play a fundamental
role in the morphogenesis of teeth and regulate all aspects of tooth development. Extensive …

Teeth develop as ectodermal appendages from epithelial and mesenchymal tissues. Tooth
organogenesis is regulated by an intricate network of cell–cell signaling during all steps of …

The teeth are vertebrate-specific, highly specialized organs performing fundamental
functions of mastication and speech, the maintenance of which is crucial for orofacial …

Teeth play essential roles in life. Their development relies on reciprocal interactions
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …

Most of the mammalian heart is formed from mesodermal progenitors in the first and second
heart fields (FHF and SHF), whereby the FHF gives rise to the left ventricle and parts of the …

Background Dental agenesis is the most common, often heritable, developmental anomaly
in humans. Mutations in MSX1, PAX9, AXIN2 and the ectodermal dysplasia genes EDA …

The embryonic surface ectoderm gives rise to the epidermis and ectodermal appendages
including hair follicles, teeth, scales, feathers, and mammary, sweat, and salivary glands …

Human WNT10A mutations are associated with developmental tooth abnormalities and
adolescent onset of a broad range of ectodermal defects. Here we show that β-catenin …

Dental pulp/dentin regeneration using dental stem cells combined with odontogenic factors
may offer great promise to treat and/or prevent premature tooth loss. Here, we investigate if …

Supernumerary teeth are common clinical dental anomalies. Although various studies have
provided abundant information regarding genes and signaling pathways involved in tooth …