RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

Specific chemical modifications of biological molecules are an efficient way of regulating
molecular function, and a plethora of downstream signalling pathways are influenced by the …

Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is
characterized by high recurrence and heterogeneity, yet its mechanism is not well …

Naive T cells undergo radical changes during the transition from dormant to hyperactive
states upon activation, which necessitates de novo protein production via transcription and …

The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Gene expression can be post-transcriptionally regulated via dynamic and reversible RNA
modifications. N 1-methyladenosine (m 1 A) is a recently identified mRNA modification; …

RNA modifications are important regulatory elements of RNA functions. However, most
genome-wide mapping of RNA modifications has focused on messenger RNAs and transfer …

The discovery of the genetic code and tRNAs as decoders of the code transformed life
science. However, after establishing the role of tRNAs in protein synthesis, the field moved …

Abstract N 1-Methyladenosine (m1A) is a prevalent post-transcriptional RNA modification,
yet little is known about its abundance, topology and dynamics in mRNA. Here, we show that …

Transfer RNA is heavily modified and plays a central role in protein synthesis and cellular
functions. Here we demonstrate that ALKBH3 is a 1-methyladenosine (m1A) and 3 …