Resting-state fMRI (rs-fMRI) has emerged as an alternative method to study brain function in
human and animal models. In humans, it has been widely used to study psychiatric …

BackgroundNumerous studies of resting-state functional imaging and voxel-based
morphometry (VBM) have revealed differences in specific brain regions of patients with …

Objective Major depressive disorder (MDD) is a ubiquitous mental illness with
heterogeneous symptoms, however, the pathophysiology mechanisms are still not fully …

Background Bipolar disorder (BD) is a mental disorder characterized by mood fluctuations
between an acute episodic state of either mania or depression and a clinically remitted state …

Brain function relies on efficient communications between distinct brain systems. The
pathology of major depressive disorder (MDD) damages functional brain networks, resulting …

Background Accumulating studies have found structural and functional abnormalities of the
striatum in bipolar disorder (BD) and major depressive disorder (MDD). However, changes …

Objectives Magnetic resonance imaging (MRI) studies comparing bipolar and unipolar
depression characterize pathophysiological differences between these conditions. However …

Background Early-onset bipolar disorder (BD) is a complex psychiatric illness characterized
by mood swings, irritability and functional impairments. To improve our understanding of the …

Background Bipolar disorder (BD) is a serious neuropsychiatric disorder characterized by
alternating periods of mania, depression, and euthymia. Abnormal spontaneous brain …

A wide homology between human and macaque striatum is often assumed as in both the
striatum is involved in cognition, emotion and executive functions. However, differences in …