Interplay between the brain and adipose tissue: a metabolic conversation

F Díaz-Castro, E Morselli, M Claret - EMBO reports, 2024 - embopress.org
The central nervous system and adipose tissue interact through complex communication.
This bidirectional signaling regulates metabolic functions. The hypothalamus, a key …

[PDF][PDF] Leptin: is it thermogenic?

AW Fischer, B Cannon, J Nedergaard - Endocrine reviews, 2020 - academic.oup.com
Animals that lack the hormone leptin become grossly obese, purportedly for 2 reasons:
increased food intake and decreased energy expenditure (thermogenesis). This review …

Brown and brite: the fat soldiers in the anti-obesity fight

S Srivastava, RL Veech - Frontiers in physiology, 2019 - frontiersin.org
Brown adipose tissue (BAT) is proposed to maintain thermal homeostasis through
dissipation of chemical energy as heat by the uncoupling proteins (UCPs) present in their …

Epiregulin induces leptin secretion and energy expenditure in high-fat diet-fed mice

R Yasmeen, Q Shen, A Lee, JH Leung… - Journal of …, 2018 - joe.bioscientifica.com
Adipokine leptin regulates neuroendocrine circuits that control energy expenditure,
thermogenesis and weight loss. However, canonic regulators of leptin secretion, such as …

Oestradiol and leptin have separate but additive anorexigenic effects and differentially target fat mass in rats

I Côté, SM Green, JF Yarrow… - Journal of …, 2018 - Wiley Online Library
We recently showed that male rats exhibit lower hypophagia and body weight loss
compared to female rats following central leptin delivery, suggesting a role for oestradiol in …