Brain ischemia is one of the principal causes of death and disability worldwide in which
prevention or an effective treatment does not exist. In order to develop successful treatments …

Preclinical mouse models are critical for understanding the pathophysiological response to
infections and developing treatment strategies for sepsis. In keeping with ethical values …

Although biomedical research is experiencing a data explosion, the accumulation of vast
quantities of data alone does not guarantee a primary objective for science: building upon …

Animal attrition in preclinical experiments can introduce bias in the estimation of causal
treatment effects, as the treatment-outcome association in surviving animals may not …

Abstract Background The inducible Kras/p53 lung adenocarcinoma mouse model, which
faithfully recapitulates human disease, is routinely initiated by the intratracheal instillation of …

Simple Summary This study assessed a humane endpoint scoring system to detect animal
suffering in a rat model of type 2 diabetes. Sprague-Dawley male rats were divided into …

The radial arm maze (RAM) is a common behavioral test to quantify spatial learning and
memory in rodents. Prior attempts to refine the standard experimental setup have been …

The fundament of an evidence-based severity assessment in laboratory animal science is
reliable distress parameters. Many readouts are used to evaluate and determine animal …

The seminar 'Severity and humane endpoints in fish research'organized by the University of
Bergen, the Industrial and Aquatic Laboratory, together with Fondazione Guido Bernadini …

A primary goal in preclinical animal research is respectful and responsible care aimed
toward minimizing stress and discomfort while enhancing collection of accurate and …