Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics

R Thapa, M Afzal, A Goyal, G Gupta, AA Bhat… - Life sciences, 2024 - Elsevier
Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor type, with a
discouragingly low survival rate and few effective treatments. An important function of the …

Hypoxia-inducible factor 1alpha and vascular endothelial growth factor in Glioblastoma Multiforme: a systematic review going beyond pathologic implications

DP Vageli, PG Doukas, K Goupou… - Oncology …, 2024 - pmc.ncbi.nlm.nih.gov
Glioblastoma multiforme (GBM) is an aggressive primary brain tumor characterized by
extensive heterogeneity and vascular proliferation. Hypoxic conditions in the tissue …

Comprehensive analysis reveals epithelial growth factor receptor as a potential diagnostic biomarker in glioblastoma multiforme

A Makawi, SA Khalafallah, IM Faris, M Alfaki - Cureus, 2024 - pmc.ncbi.nlm.nih.gov
Glioblastoma multiforme (GBM), a highly aggressive tumor of the central nervous system, is
the most common malignant brain tumor and poses a significant risk to life. GBM patients …

[HTML][HTML] Predictive and Prognostic Significance of Molecular Biomarkers in Glioblastoma

S Shah, A Nag, SV Sachithanandam, B Lucke-Wold - Biomedicines, 2024 - mdpi.com
Glioblastoma multiforme (GBM), a WHO grade 4 glioma, is the most common and
aggressive primary brain tumor, characterized by rapid progression and poor prognosis. The …

PAQR4 oncogene: a novel target for cancer therapy

D Patil, S Raut, M Joshi, P Bhatt, LK Bhatt - Medical Oncology, 2024 - Springer
Despite decades of basic and clinical research and trials of promising new therapies, cancer
remains a major cause of morbidity and mortality due to the emergence of drug resistance to …

Chitosan Functionalized Skin-Adhesive Formulation for Ergotamine Delivery in Melanoma Treatment

F Azhar, H Naureen, G Shahnaz, SDA Hamdani… - BioNanoScience, 2025 - Springer
This study develops a skin-penetrating drug delivery system of thiolated chitosan-lithocholic
acid nanomicelles for the treatment of melanoma. In this regard, ergotamine was selected as …

[HTML][HTML] Complex Diagnostic Challenges in Glioblastoma: The Role of 18F-FDOPA PET Imaging

D Sipos, Z Debreczeni-Máté, Z Ritter, O Freihat… - Pharmaceuticals, 2024 - mdpi.com
Glioblastoma multiforme (GBM) remains one of the most aggressive and lethal forms of brain
cancer, characterized by rapid proliferation and diffuse infiltration into the surrounding brain …

[HTML][HTML] Mesenchymal-Type Genetic Mutations Are Likely Prerequisite for Glioblastoma Multiforme to Metastasize Outside the Central Nervous System: An Original …

BJ Laurin, R Treffy, JM Connelly, M Straza… - World Neurosurgery, 2024 - Elsevier
Background Glioblastoma multiforme (GBM) is the most aggressive and prevalent type of
malignant brain tumor, yet it metastasizes outside the central nervous system (CNS) in 0.4 …

Preliminary Analysis of Solute Carrier Family in Nucleotide Rescue Synthesis in Glioma

Y Chen, Q Sun, Z Li - Journal of Craniofacial Surgery, 2024 - journals.lww.com
Glioma is a highly proliferative and aggressive tumor type that arises from glial cells in the
central nervous system. The nucleotides required for the proliferation and replication of …

Unraveling the Role of Transcription Factor SP1 and H3K9 Acetylation in MGMT Regulation and Temozolomide Resistance in Glioblastoma Multiforme

L Gu, Y Wang, H Xing, P Hu, Y Wang, W Ma - 2023 - researchsquare.com
Glioblastoma multiforme (GBM) is recognized as a highly aggressive brain tumor, exhibiting
profound resistance to temozolomide (TMZ) chemotherapy. While methylation of the MGMT …