Naïve CD4 T cells, on activation, differentiate into distinct T helper (Th) subsets that produce
lineage-specific cytokines. By producing unique sets of cytokines, effector Th subsets play …

The multifaceted organization of the immune system involves not only patrolling
lymphocytes that constantly monitor antigen-presenting cells in secondary lymphoid organs …

Polycystic ovary syndrome (PCOS) is characterized by androgen excess, ovulatory
dysfunction and polycystic ovaries, and is often accompanied by insulin resistance. The …

Animal models have highlighted the importance of innate lymphoid cells (ILCs) in multiple
immune responses. However, technical limitations have hampered adequate …

Innate lymphoid cells (ILCs) are critical mediators of mucosal immunity, and group 1 ILCs
(ILC1 cells) and group 3 ILCs (ILC3 cells) have been shown to be functionally plastic. Here …

Skin-resident CD8+ T cells include distinct interferon-γ–producing [tissue-resident memory T
type 1 (TRM1)] and interleukin-17 (IL-17)–producing (TRM17) subsets that differentially …

Innate lymphoid cells (ILCs) play key roles in host defense, barrier integrity, and
homeostasis and mirror adaptive CD4+ T helper (Th) cell subtypes in both usage of effector …

Immune cells and epithelium form sophisticated barrier systems in symbiotic relationships
with microbiota. Evidence suggests that immune cells can sense microbes through intact …

The GATA family of transcription factors is of crucial importance during embryonic
development, playing complex and widespread roles in cell fate decisions and tissue …

Innate lymphoid cells (ILCs) are important for mucosal immunity. The intestine harbors all
ILC subsets, but how these cells are balanced to achieve immune homeostasis and mount …