[HTML][HTML] Medulloblastoma in the modern era: review of contemporary trials, molecular advances, and updates in management

MA Lazow, JD Palmer, M Fouladi, R Salloum - Neurotherapeutics, 2022 - Elsevier
Critical discoveries over the past two decades have transformed our understanding of
medulloblastoma from a single entity into a clinically and biologically heterogeneous …

EANO–EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma

E Franceschi, S Hofer, AA Brandes, D Frappaz… - The Lancet …, 2019 - thelancet.com
Summary The European Association of Neuro-Oncology (EANO) and EUropean RAre
CANcer (EURACAN) guideline provides recommendations for the diagnosis, treatment, and …

Adult medulloblastoma comprises three major molecular variants

M Remke, T Hielscher, PA Northcott, H Witt… - Journal of clinical …, 2011 - ascopubs.org
Purpose Medulloblastoma is a rare primary brain tumor in adults, whereas it constitutes the
most common malignant brain tumor in children. Integrated genomics approaches revealed …

Proton beam craniospinal irradiation reduces acute toxicity for adults with medulloblastoma

AP Brown, CL Barney, DR Grosshans… - International Journal of …, 2013 - Elsevier
PURPOSE: Efficacy and acute toxicity of proton craniospinal irradiation (p-CSI) were
compared with conventional photon CSI (x-CSI) for adults with medulloblastoma. METHODS …

Clinical and mutational profiles of adult medulloblastoma groups

GCH Wong, KKW Li, WW Wang, APY Liu… - Acta neuropathologica …, 2020 - Springer
Adult medulloblastomas are clinically and molecularly understudied due to their rarity. We
performed molecular grouping, targeted sequencing, and TERT promoter Sanger …

Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification

A Korshunov, M Remke, W Werft, A Benner… - Journal of clinical …, 2010 - ascopubs.org
Purpose Medulloblastoma (MB) is the most common malignant brain tumor in children,
whereas it rarely presents in adults. We aimed to identify genetic aberrations in 146 adult …

Molecular subgroups of adult medulloblastoma: a long-term single-institution study

F Zhao, H Ohgaki, L Xu, F Giangaspero, C Li… - Neuro …, 2016 - academic.oup.com
Background Recent transcriptomic approaches have demonstrated that there are at least 4
distinct subgroups in medulloblastoma (MB); however, survival studies of molecular …

Relative survival of childhood and adult medulloblastomas and primitive neuroectodermal tumors (PNETs)

NR Smoll - Cancer, 2012 - Wiley Online Library
BACKGROUND: Medulloblastomas are 1 of the most common brain tumors in children but
can affect individuals of all ages. For this report, the author investigated the impact of …

Incidence, risks, and sequelae of posterior fossa syndrome in pediatric medulloblastoma

MP Korah, N Esiashvili, CM Mazewski… - International Journal of …, 2010 - Elsevier
PURPOSE: To investigate the incidence, risks, severity, and sequelae of posterior fossa
syndrome (PFS) in children with medulloblastoma. METHODS AND MATERIALS: Between …

Management and Long-term Outcomes of Adults With Medulloblastoma

BJ Neth, A Raghunathan, SH Kizilbash, JH Uhm… - Neurology, 2023 - AAN Enterprises
Background and Objectives Medulloblastomas are embryonal tumors predominantly
affecting children. Recognition of molecularly defined subgroups has advanced …