Synthetic molecules that can bind with high sequence specificity to a chosen target in a
gene sequence are of major interest in medicinal and biotechnological contexts. They show …

Abstract Peptide Nucleic Acid (PNA) is a powerful new biomolecular tool with a wide range
of important applications. PNA mimics the behaviour of DNA and binds complementary …

Since the elucidation of the double helical structure of DNA (deoxyribonucleic acid), our
genetic material, the properties of this remarkable molecule have fascinated chemists, and …

The astonishing discovery that peptide nucleic acids (PNAs, B= nucleobase), in spite of their
drastic structural difference to natural DNA, are better nucleic acid mimetics than many other …

Peptide nucleic acid (PNA) is a DNA mimic having a pseudopeptide backbone that makes it
extremely stable in biological fluids. PNA binds complementary RNA and DNA with high …

Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a
most dramatic departure from the native structure of DNA. The present review summarizes …

We have constructed light-up probes for nucleic acid detection. The light-up probe is a
peptide nucleic acid (PNA) oligonucleotide to which the asymmetric cyanine dye thiazole …

DNA self-assembly has proved to be a useful bottom-up strategy for the construction of user-
defined nanoscale objects, lattices and devices. The design of these structures has largely …

For development of ideal antisense and antigene molecules, various chemical modifications
of oligonucleotides have been studied. However, despite their importance, there is only …

The important role that noncoding RNA plays in cell biology makes it an attractive target for
molecular recognition. However, the discovery of small molecules that bind double helical …