Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome
characterized by impaired speech development and linguistic deficits. Recent genomic …

Evidence for the etiology of autism spectrum disorders (ASDs) has consistently pointed to a
strong genetic component complicated by substantial locus heterogeneity,. We sequenced …

Background Rare mutations affecting the FOXP2 transcription factor cause a monogenic
speech and language disorder. We hypothesized that neural pathways downstream of …

It has been proposed that two amino acid substitutions in the transcription factor FOXP2
have been positively selected during human evolution due to effects on aspects of speech …

Forkhead-box protein P2 is a transcription factor that has been associated with intriguing
aspects of cognitive function in humans, non-human mammals, and song-learning birds …

Mutations in FOXP2, a member of the forkhead family of transcription factor genes, are the
only known cause of developmental speech and language disorders in humans. To date …

The most well-described example of an inherited speech and language disorder is that
observed in the multigenerational KE family, caused by a heterozygous missense mutation …

Heterozygous mutations in FOXP2, which encodes a forkhead transcription factor, have
been shown to cause developmental verbal dyspraxia and language impairment. FOXP2 …

We previously discovered that mutations of the human FOXP2 gene cause a monogenic
communication disorder, primarily characterized by difficulties in learning to make …