A Comprehensive Review of HLA and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine

C Kloypan, N Koomdee, P Satapornpong, T Tempark… - Pharmaceuticals, 2021 - mdpi.com
Human leukocyte antigen (HLA) encoded by the HLA gene is an important modulator for
immune responses and drug hypersensitivity reactions as well. Genetic polymorphisms of …

Current perspectives on severe drug eruption

J Zhang, Z Lei, C Xu, J Zhao, X Kang - Clinical Reviews in Allergy & …, 2021 - Springer
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe
drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are …

[HTML][HTML] Drug-induced severe cutaneous adverse reactions: insights into clinical presentation, immunopathogenesis, diagnostic methods, treatment, and …

T Tempark, S John, P Rerknimitr… - Frontiers in …, 2022 - frontiersin.org
SCARs are rare and life-threatening hypersensitivity reactions. In general, the increased
duration of hospital stays and the associated cost burden are common issues, and in the …

[HTML][HTML] Mechanism of lethal skin toxicities induced by epidermal growth factor receptor inhibitors and related treatment strategies

Y Li, R Fu, T Jiang, D Duan, Y Wu, C Li, Z Li… - Frontiers in …, 2022 - frontiersin.org
Epidermal growth factor receptor (EGFR) inhibitors are widely used to treat various types of
cancers such as non-small cell lung cancer, head and neck cancer, breast cancer …

Acute generalized exanthematous pustulosis: clinical features, differential diagnosis, and management

R Parisi, H Shah, AA Navarini, B Muehleisen… - American Journal of …, 2023 - Springer
Acute generalized exanthematous pustulosis (AGEP) is a rare, acute, severe cutaneous
adverse reaction mainly attributed to drugs, although other triggers, including infections …

Acute generalized exanthematous pustulosis following SARS‐CoV‐2 Virus: remdesivir as a suspected culprit

F Mohaghegh, P Hatami, Z Aryanian… - Case Reports in …, 2022 - Wiley Online Library
Acute generalized exanthematous pustulosis (AGEP) is an exanthematous condition,
predominantly occurring as a result of drug reactions. We, hereby, present the first case of …

Patient care outcomes in hospitalized patients with acute generalized exanthematous pustulosis: a cross-sectional database study

KB Nusbaum, TD Walker, S Himed, JC Trinidad… - American Journal of …, 2023 - Springer
Background Current understanding of the etiology, natural history, and outcomes of acute
generalized exanthematous pustulosis (AGEP) has been limited, with most available studies …

[HTML][HTML] Acute generalized exanthematous pustulosis in close temporal association with mRNA-1273 vaccine

F Mitri, F Toberer, M HARTMANN - Acta Dermato-Venereologica, 2021 - ncbi.nlm.nih.gov
DISCUSSION AGEP is a severe cutaneous adverse reaction with rapid onset (1). It is usually
drug-induced and is rarely of infectious aetiology. It is characterized by an acute rash with …

Clinical features of acute generalized exanthematous pustulosis caused by hydroxychloroquine in rheumatology patients and exploration of CARD14 gene mutations

F Luo, X Yuan, H Xiong, Y Yang, C Chen, W Ma… - Frontiers in …, 2023 - frontiersin.org
Acute generalized exanthematous pustulosis (AGEP) is a rare condition characterized by
superficial pustules following drug ingestion or infection. Currently, there is no clear link …

[HTML][HTML] Case report: successful treatment of acute generalized exanthematous pustulosis with secukinumab

L Zhang, Q Xu, T Lin, S Ruan, M Lin, C Bao… - Frontiers in …, 2021 - frontiersin.org
Acute generalized exanthematous pustulosis is a severe, usually drug-related reaction,
characterized by an acute onset of mainly small non-follicular pustules on an erythematous …