Objective To summarize evidence for use of advanced MRI techniques as monitoring
biomarkers in the clinic, and to highlight the latest bench-to-bedside developments. Methods …

Magnetic resonance spectroscopy is a powerful, non-invasive, quantitative imaging
technique that allows for the measurement of brain metabolites that has demonstrated utility …

Short‐TE proton MRS is used to study metabolism in the human brain. Common analysis
methods model the data as a linear combination of metabolite basis spectra. This large …

Magnetic resonance spectroscopy (MRS) is a non-invasive neuroimaging technique used to
measure brain chemistry in vivo and has been used to study the healthy brain as well as …

In vivo magnetic resonance spectroscopy (MRS) is a powerful tool for biomedical research
and clinical diagnostics, allowing for non-invasive measurement and analysis of small …

Edited MRS sequences are widely used for studying γ‐aminobutyric acid (GABA) in the
human brain. Several algorithms are available for modelling these data, deriving metabolite …

Attention-deficit hyperactive disorder (ADHD) is characterized by inattention and increased
impulsive and hypermotoric behaviors. Despite the high prevalence and impact of ADHD …

Expert consensus recommends linear‐combination modeling (LCM) of 1H MR spectra with
sequence‐specific simulated metabolite basis function and experimentally derived …

Millions of children sustain a concussion annually. Concussion disrupts cellular signaling
and neural pathways within the brain but the resulting metabolic disruptions are not well …

Creatine transporter deficiency (CTD), caused by pathogenic variants in SLC6A8, is the
second most common cause of X-linked intellectual disability. Symptoms include intellectual …