Effects of chronic fluoxetine treatment on anxiety-and depressive-like behaviors in adolescent rodents–systematic review and meta-analysis

J Kryst, I Majcher-Maślanka, A Chocyk - Pharmacological Reports, 2022 - Springer
Background Drugs prescribed for psychiatric disorders in adolescence should be studied
very extensively since they can affect developing and thus highly plastic brain differently …

Boosting neurogenesis in the adult hippocampus using antidepressants and mesenchymal stem cells

M Kot, PK Neglur, A Pietraszewska, L Buzanska - Cells, 2022 - mdpi.com
The hippocampus is one of the few privileged regions (neural stem cell niche) of the brain,
where neural stem cells differentiate into new neurons throughout adulthood. However …

Long-term overconsumption of sugar starting at adolescence produces persistent hyperactivity and neurocognitive deficits in adulthood

K Beecher, I Alvarez Cooper, J Wang… - Frontiers in …, 2021 - frontiersin.org
Sugar has become embedded in modern food and beverages. This has led to
overconsumption of sugar in children, adolescents, and adults, with more than 60 countries …

Effects of adolescent administration of fluoxetine on novel object recognition memory, anxiety-like behaviors, and hippocampal brain-derived neurotrophic factor level

F Sadegzadeh, N Sakhaie, R Dehghany, O Adak… - Life sciences, 2020 - Elsevier
Aims Fluoxetine (FLX) is a common selective serotonin reuptake inhibitor, which is used in
adolescents with psychiatric disorders. Controversial results have been obtained in different …

Enduring effects of adolescent ketamine exposure on cocaine-and sucrose-induced reward in male and female C57BL/6 mice

I Garcia-Carachure, FJ Flores-Ramirez… - …, 2020 - nature.com
Ketamine has shown promising antidepressant efficacy for adolescent treatment-resistant
depression. However, the potential enduring consequences of ketamine exposure have not …

Chronic social defeat stress in prairie voles (Microtus ochrogaster): A preclinical model for the study of depression-related phenotypes

M Rodriguez, A Themann, I Garcia-Carachure… - Journal of Affective …, 2024 - Elsevier
Background Stress-induced illnesses, like major depression, are among the leading causes
of disability across the world. Consequently, there is a dire need for the validation of …

[HTML][HTML] Sex-Specific Alterations in Spatial Memory and Hippocampal AKT-mTOR Signaling in Adult Mice Pre-exposed to Ketamine and/or Psychological Stress …

I Garcia-Carachure, O Lira, A Themann… - … psychiatry global open …, 2024 - Elsevier
Background Ketamine (KET) is administered to manage major depression in adolescent
patients. However, the long-term effects of juvenile KET exposure on memory-related tasks …

Adolescent fluoxetine treatment mediates a persistent anxiety-like outcome in female C57BL/6 mice that is ameliorated by fluoxetine re-exposure in adulthood

FJ Flores-Ramirez, A Themann, JA Sierra-Fonseca… - Scientific reports, 2021 - nature.com
The objective of this study was to evaluate whether juvenile fluoxetine (FLX) exposure
induces long-term changes in baseline responses to anxiety-inducing environments, and if …

Adolescent fluoxetine exposure induces persistent gene expression changes in the hippocampus of adult male C57BL/6 mice

SD Iñiguez, FJ Flores-Ramirez, A Themann… - Molecular neurobiology, 2021 - Springer
Mood-related disorders have a high prevalence among children and adolescents, posing a
public health challenge, given their adverse impact on these young populations. Treatment …

Early-life ketamine exposure attenuates the preference for ethanol in adolescent Sprague-Dawley rats

D Franco, J Zamudio, KM Blevins… - Behavioural brain …, 2020 - Elsevier
Ketamine, a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, produces
quick and effective antidepressant results in depressed juvenile and adult individuals. The …