Normal brain function requires a tightly regulated balance between excitatory and inhibitory
neurotransmissions. γ‐Aminobutyric acid type A (GABAA) receptors represent the major …

Many patients with developmental and epileptic encephalopathies present with variants in
genes coding for GABAA receptors. These variants are presumed to cause loss-of-function …

Objective Cannabidiol (CBD) has been approved by the US Food and Drug Administration
(FDA) to treat intractable childhood epilepsies, such as Dravet syndrome and Lennox …

Background and Purpose Cannabis has been used to treat epilepsy for millennia, with such
use validated by regulatory approval of cannabidiol (CBD) for Dravet syndrome …

Communication between nerve cells depends on the balance between excitatory and
inhibitory circuits. GABA, the major inhibitory neurotransmitter, regulates this balance and …

A potential link between GABRD encoding the δ subunit of extrasynaptic GABAA receptors
and neurodevelopmental disorders has largely been disregarded due to conflicting …

Background Variants in GABRB2, encoding the β2 subunit of the γ-aminobutyric acid type A
(GABA A) receptor, can result in a diverse range of conditions, ranging from febrile seizures …

γ-Aminobutyric-acid type A (GABA A) receptors expressing the γ1 or γ3 subunit are only
found within a few regions of the brain, some of which are involved in sleep. No known …

Objective Variants in GABRA1 have been associated with a broad epilepsy spectrum,
ranging from genetic generalized epilepsies to developmental and epileptic …

Recent discoveries have revealed that genetic variants in γ-aminobutyric acid type A
(GABAA) receptor subunits can lead to both gain-of-function (GOF) and loss-of-function …