In multicellular organisms, interactions between cells and intercellular communications form
the very basis of the organism's survival, the functioning of its systems, the maintenance of …

The acquisition of resistance to traditional chemotherapy and the chemoresistant metastatic
relapse of minimal residual disease both play a key role in the treatment failure and poor …

Using meta-analyses, we introduce a unicellular attractor (UCA) model integrating essential
features of the 'atavistic reversal','cancer attractor','somatic mutation','genome chaos', and …

Cancer-associated fibroblasts paly critical roles in regulating cancer cell biological
properties by intricate and dynamic communication networks. But the mechanism of CAFs in …

Tumor microenvironment (TME) has been demonstrated to play a significant role in tumor
initiation, progression, and metastasis. Cancer-associated fibroblasts (CAFs) are the major …

For determining the malignant behavior of a tumor, paracrine interactions between stromal
and cancer cells are crucial. We previously reported that fibroblast clustering induces …

Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours
are known as tumour-associated macrophages (TAMs). These specialized immune cells …

Epidemiological observations, experimental studies and clinical data show that obesity is
associated with a higher risk of developing different types of cancer; however, proof of a …

Simple Summary Cancer-associated fibroblasts (CAFs) are a key pro-tumorigenic cell type
in the tumor microenvironment; however, treatments targeting these cells have shown …

The functional heterogeneity and ecological niche of prostate cancer stem cells (PCSCs),
which are major drivers of prostate cancer development and treatment resistance, have …