Head and neck cancers are a heterogeneous group of tumors that are highly aggressive
and collectively represent the sixth most common cancer worldwide. Ninety percent of head …

The immune system is the hard-wired host defense mechanism against pathogens as well
as cancer. Five years ago, we pondered the question if the era of cancer immunotherapy …

Background Head and neck squamous cell carcinoma (HNSCC), the most common head
and neck cancer, is highly aggressive and heterogeneous, resulting in variable prognoses …

Background We conducted a meta-analysis to evaluate the efficacy of anti-programmed cell
death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) monotherapy or immunotherapy …

Background Immune checkpoint inhibitors (ICI) are active in patients with
recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). Recent …

Rationale: NRF2, a redox sensitive transcription factor, is up-regulated in head and neck
squamous cell carcinoma (HNSCC), however, the associated impact and regulatory …

Understanding of oropharyngeal squamous cell carcinoma has significantly progressed
over the last decades, and the concept that this disease can be subdivided into two distinct …

Head and neck squamous cell carcinomas (HNSCCs) are a type of common malignant
tumor, mainly manifesting as oropharyngeal, oral cavity, laryngopharyngeal …

Immunotherapy for skin malignancies has ushered in a new era for cancer treatments by
demonstrating unprecedented durable responses in the setting of metastatic Melanoma …

Myeloid Derived suppressor cells (MDSCs) play a key role in the progression and
recurrence of human malignancies and in restraining the efficacy of adjuvant therapies. We …