As both natural selection and population history can affect genome-wide patterns of
variation, disentangling the contributions of each has remained as a major challenge in …

The explosion in population genomic data demands ever more complex modes of analysis,
and increasingly, these analyses depend on sophisticated simulations. Recent advances in …

The relative evolutionary roles of adaptive and non-adaptive processes remain a central
question in population genetics. Resolution of this debate has been difficult as an …

Current procedures for inferring population history generally assume complete neutrality—
that is, they neglect both direct selection and the effects of selection on linked sites. We here …

Chromosomal inversions contribute widely to adaptation and speciation, yet they present a
unique evolutionary puzzle as both their allelic content and frequency evolve in a feedback …

While it is appreciated that population size changes can impact patterns of deleterious
variation in natural populations, less attention has been paid to how gene flow affects and is …

Inferring the demographic history of populations provides fundamental insights into species
dynamics and is essential for developing a null model to accurately study selective …

Genomic data encode past evolutionary events and have the potential to reveal the strength,
rate and biological drivers of adaptation. However, joint estimation of adaptation rate (α) and …

The effect of a mutation on fitness may differ between populations depending on
environmental and genetic context, but little is known about the factors that underlie such …

The role of rare alleles in complex phenotypes has been hotly debated, but most rare variant
association tests (RVATs) do not account for the evolutionary forces that affect genetic …