In the last few years there has been a veritable explosion of knowledge about cyclic
nucleotide phosphodiesterases. In particular, the accumulating data showing that there are …

Phototransduction is the process by which light triggers an electrical signal in a
photoreceptor cell. Image-forming vision in vertebrates is mediated by two types of …

How one goes about analyzing proteins is a constantly evolving field that is no longer solely
the domain of the protein biochemist. Investi gators from diverse disciplines find themselves …

260 J. Griinler et al./Biochimica et Biophysics Acta 1212 (1994) 259-277 way, three acetyl-
CoA units are condensed to 3-hydroxy-3-methylglutaryyl CoA (HMG-COA), which is then …

Irish setter dogs affected with a rod/cone dysplasia (locus designation, rcd1) display
markedly elevated levels of retinal cGMP during postnatal development. The photoreceptor …

Arf‐like (Arl) proteins are close relatives of the Arf regulators of vesicular transport, but their
function is unknown. Here, we present the crystal structure of full‐length Arl2‐GTP in …

Many isoprenylated proteins are known to participate in signal transduction, but not all have
been identified. Using an in vitro prenylation screen, two human cDNAs (PTPcaaxI and …

The locus for autosomal dominant congenital stationary night blindness (adCSNB) has
recently been assigned to distal chromosome 4p by linkage analysis in a large Danish …

Abstract Phosphodiesterase 6 (PDE6) is highly concentrated in the retina. It is most
abundant in the internal membranes of retinal photoreceptors, where it reduces cytoplasmic …

Arf-like protein 3 (ARL3) is a ubiquitous small GTPase expressed in ciliated cells of plants
and animals. Germline deletion of Arl3 in mice causes multiorgan ciliopathy reminiscent of …