Ionic currents and the network-driven patterns they generate differ in immature and adult
neurons: The developing brain is not a “small adult brain.” One of the most investigated …

The developing brain is talkative but its language is not that of the adult. Most if not all
voltage and transmitter-gated ionic currents follow a developmental sequence and network …

Recent years have witnessed a steep increase in studies on the diverse roles of neuronal
cation-chloride cotransporters (CCCs). The versatility of CCC gene transcription …

In physiological conditions, adult neurons have low intracellular Cl−[(Cl−) I] levels
underlying the γ-aminobutyric acid (GABA) ergic inhibitory drive. In contrast, neurons have …

Background and purpose: Earlier studies had demonstrated that tonic–clonic seizure‐like
events (SLEs) resembling electrographic correlates of limbic seizures in animals and …

Epilepsy often develops in patients with glioma, and the two conditions share common
pathogenic mechanisms. Altered expression of glutamate transporters, including the cystine …

As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid
(GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride …

In cortical and hippocampal neurons, cation-chloride cotransporters (CCCs) control the
reversal potential (EGABA) of GABAA receptor-mediated current and voltage responses …

GABA is the main inhibitory neurotransmitter in the adult forebrain, where it activates
ionotropic type A and metabotropic type B receptors. Early studies have shown that GABAA …

The development of a balance between excitatory and inhibitory synapses is a critical
process in the generation and maturation of functional circuits. Accumulating evidence …