Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

NLRP3 inflammasome in endothelial dysfunction

B Bai, Y Yang, QI Wang, M Li, C Tian, Y Liu… - Cell death & …, 2020 - nature.com
Inflammasomes are a class of cytosolic protein complexes. They act as cytosolic innate
immune signal receptors to sense pathogens and initiate inflammatory responses under …

Treatment of intervertebral disc degeneration

J Xin, Y Wang, Z Zheng, S Wang, S Na… - Orthopaedic …, 2022 - Wiley Online Library
Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low
back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high …

miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

S Zhou, J Jin, J Wang, Z Zhang, JH Freedman… - Acta Pharmacologica …, 2018 - nature.com
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the
world. Although considerable progress has been made in the diagnosis, treatment and …

The novel regulatory role of lnc RNA‐mi RNA‐mRNA axis in cardiovascular diseases

Y Huang - Journal of cellular and molecular medicine, 2018 - Wiley Online Library
Long noncoding RNA s (lnc RNA s) are RNA s longer than 200 nt in length that are
characterized by low levels of sequence conservation and expression; lnc RNA s modulate …

Non-coding RNAs regulating mitochondrial function in cardiovascular diseases

X Ao, W Ding, X Li, Q Xu, X Chen, X Zhou… - Journal of Molecular …, 2023 - Springer
Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and
a significant obstacle to improving patients' health and lives. Mitochondria are core …

Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease

D Santovito, C Weber - Nature Reviews Cardiology, 2022 - nature.com
Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Preclinical and clinical development of noncoding RNA therapeutics for cardiovascular disease

CK Huang, S Kafert-Kasting, T Thum - Circulation research, 2020 - Am Heart Assoc
RNA modulation has become a promising therapeutic approach for the treatment of several
types of disease. The emerging field of noncoding RNA-based therapies has now come to …

[HTML][HTML] Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets

C Wang, Z Li, Y Liu, L Yuan - Theranostics, 2021 - ncbi.nlm.nih.gov
Exosomes are nanosized lipid vesicles originating from the endosomal system that carry
many macromolecules from their parental cells and play important roles in intercellular …

[HTML][HTML] MicroRNA and cardiovascular diseases

HA Çakmak, M Demir - Balkan medical journal, 2020 - ncbi.nlm.nih.gov
Cardiovascular diseases are one of the most common causes of death in both developing
and developed countries worldwide. Even though there have been improvements in primary …