Designing macrocyclic disulfide-rich peptides for biotechnological applications
Bioactive peptides have potential as drug leads, but turning them into drugs is a challenge
because of their typically poor metabolic stability. Molecular grafting is one approach to …
because of their typically poor metabolic stability. Molecular grafting is one approach to …
[HTML][HTML] Scorpion venom peptides: Molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers
Z Xia, D He, Y Wu, HF Kwok, Z Cao - Pharmacological Research, 2023 - Elsevier
Animal venom is an important evolutionary innovation in nature. As one of the most
representative animal venoms, scorpion venom contains an extremely diverse set of …
representative animal venoms, scorpion venom contains an extremely diverse set of …
The defensins consist of two independent, convergent protein superfamilies
The defensin and defensin-like proteins are an extensive group of small, cationic, disulfide-
rich proteins found in animals, plants, and fungi and mostly perform roles in host defense …
rich proteins found in animals, plants, and fungi and mostly perform roles in host defense …
Chlorotoxin: Structure, activity, and potential uses in cancer therapy
Chlorotoxin is a disulfide‐rich stable peptide from the venom of the Israeli scorpion Leiurus
quinquestriatus, which has potential therapeutic applications in the treatment of cancer. Its …
quinquestriatus, which has potential therapeutic applications in the treatment of cancer. Its …
Glioblastoma multiforme targeted therapy: The Chlorotoxin story
O Cohen-Inbar, M Zaaroor - Journal of Clinical Neuroscience, 2016 - Elsevier
Glioblastoma multiforme (GBM) is the most common malignant primary brain neoplasm
having a mean survival of< 24 months. Scorpion toxins are considered promising cancer …
having a mean survival of< 24 months. Scorpion toxins are considered promising cancer …
Scorpion venomics: a 2019 overview
JI Cid-Uribe, JI Veytia-Bucheli… - Expert review of …, 2020 - Taylor & Francis
Introduction: A few scorpions are dangerous to humans. Their medical relevance was the
initial driving force for venom research. By classical biochemistry and molecular cloning …
initial driving force for venom research. By classical biochemistry and molecular cloning …
Oxidative Post-Translational Modifications: A Focus on Cysteine S-Sulfhydration and the Regulation of Endothelial Fitness
SI Bibli, I Fleming - Antioxidants & Redox Signaling, 2021 - liebertpub.com
Significance: Changes in the oxidative balance can affect cellular physiology and adaptation
through redox signaling. The endothelial cells that line blood vessels are particularly …
through redox signaling. The endothelial cells that line blood vessels are particularly …
A deep learning approach with data augmentation to predict novel spider neurotoxic peptides
As major components of spider venoms, neurotoxic peptides exhibit structural diversity,
target specificity, and have great pharmaceutical potential. Deep learning may be an …
target specificity, and have great pharmaceutical potential. Deep learning may be an …
From venoms to BBB-shuttles. MiniCTX3: a molecular vector derived from scorpion venom
C Díaz-Perlas, M Varese, S Guardiola… - Chemical …, 2018 - pubs.rsc.org
The present study aims to develop chlorotoxin (CTX), from Giant Yellow Israeli scorpion
venom, as a new BBB-shuttle. Minimised versions of CTX were prepared to reduce its …
venom, as a new BBB-shuttle. Minimised versions of CTX were prepared to reduce its …
A C-terminal fragment of chlorotoxin retains bioactivity and inhibits cell migration
Chlorotoxin was originally isolated from the venom of the Israeli scorpion Leiurus
quinquestriatus, and has potential as a tumor imaging agent based on its selective binding …
quinquestriatus, and has potential as a tumor imaging agent based on its selective binding …