Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

Accumulation of excess iron in the body, or systemic iron overload, results from a variety of
causes. The concentration of iron in the liver is linearly related to the total body iron stores …

Hemochromatosis | New England Journal of Medicine Skip to main content The New England
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T2* relaxation refers to decay of transverse magnetization caused by a combination of spin-
spin relaxation and magnetic field inhomogeneity. T2* relaxation is seen only with gradient …

Before the introduction of erythropoiesis-stimulating agents (ESAs) in 1989, repeated
transfusions given to patients with end-stage renal disease caused iron overload, and the …

Measurement of liver iron concentration (LIC) is necessary for a range of iron-loading
disorders such as hereditary hemochromatosis, thalassemia, sickle cell disease, aplastic …

Liver iron overload is the histological hallmark of hereditary hemochromatosis and
transfusional hemosiderosis, and can also occur in chronic hepatopathies. Iron overload can …

Iron overload is a systemic disorder and is either primary (genetic) or secondary (exogenous
iron administration). Primary iron overload is most commonly associated with hereditary …

Haemochromatosis is now known to be an iron-storage disease with genetic heterogeneity
but with a final common metabolic pathway resulting in inappropriately low production of the …

Iron overload in humans is associated with a variety of genetic and acquired conditions. Of
these, HFE hemochromatosis (HFE-HC) is by far the most frequent and most well-defined …