Sialic acid–binding Ig-like lectins, or Siglecs, vary in their specificity for sialic acid–
containing ligands and are mainly expressed by cells of the immune system. Many Siglecs …

Since the original identification of microglia as a principal player in the brain's innate
immune response, microglial activation has been widely studied. Recent studies suggest …

In the arms race of host–microbe co-evolution, successful microbial pathogens have evolved
ingenious ways to evade host immune responses. In this Review, we focus on'crosstalk …

The response of innate immune cells to growth factors, immune complexes, extracellular
matrix proteins, cytokines, pathogens, cellular damage, and many other stimuli is regulated …

Signal transduction by the T-cell antigen receptor (TCR) is initiated by phosphorylation of
conserved motifs (ITAMs) contained within the cytoplasmic domains of the invariant …

Immune homeostasis is regulated by a finely tuned network of positive–negative regulatory
mechanisms that guarantees proper surveillance avoiding hyperactivity that would lead to …

Immunoglobulin A (IgA) is the most abundantly produced antibody isotype in mammals. The
primary function of IgA is to maintain homeostasis at mucosal surfaces and play a role in …

FGFRL1 (fibroblast growth factor receptor like 1) is the most recently discovered member of
the FGFR family. It contains three extracellular Ig-like domains similar to the classical …

Different dendritic cell (DC) subsets have distinct specialized functions contributed in part by
their differential expression of pattern recognition receptors (PRRs). C‐type lectin receptors …

Natural antibodies are produced by B lymphocytes in the absence of external antigen
stimulation. With their ability to recognize self, altered self and foreign antigens, they …