Selective destruction of neoplastic tissues by oncolytic viruses (OVs) leads to antigen-
agnostic boosting of neoantigen-specific cytotoxic T lymphocyte (CTL) responses, making …

Recent work shows that after stimulation with antigen, CD4+ and CD8+ T cells embark on a
programme of proliferation that is closely linked with the acquisition of effector functions and …

A cytomegalovirus (CMV) vaccine that is effective at preventing congenital infection and
reducing CMV disease in transplant patients remains a high priority as no approved …

Adoptive cell transfer after host preconditioning by lymphodepletion represents an important
advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment …

Perforin/granzyme-induced apoptosis is the main pathway used by cytotoxic lymphocytes to
eliminate virus-infected or transformed cells. Studies in gene-disrupted mice indicate that …

The leading malaria vaccine in development is the circumsporozoite protein (CSP)-based
particle vaccine, RTS, S, which targets the pre-erythrocytic stage of Plasmodium falciparum …

Depletion of immune elements before adoptive cell transfer (ACT) can dramatically improve
the antitumor efficacy of transferred CD8+ T cells, but the specific mechanisms that …

It remains difficult to treat the multiplicity of distinct viral infections that afflict
immunocompromised patients. Adoptive transfer of virus-specific T cells (VSTs) can be safe …

Adoptive cell transfer (ACT) of purified naive, stem cell memory, and central memory T cell
subsets results in superior persistence and antitumor immunity compared with ACT of …

The discovery of multiple costimulatory cell surface molecules that influence the course of T
cell activation has increased our appreciation of the complexity of the T cell response. It …