Opioid-related mortality is a growing problem in the United States, and in 2015 there were
over 33,000 opioid-related deaths. To combat this mortality trend, naloxone is increasingly …

Naloxone is a well-established essential medicine for the treatment of life-threatening
heroin/opioid overdose in emergency medicine. Over two decades, the concept of 'take …

Acute opioid intoxication and overdose are common causes of presentation to emergency
departments. Although naloxone, a pure opioid antagonist, has been available for many …

Introduction: Opioid overdose fatality has increased threefold since 1999. As a result,
prescription drug overdose surpassed motor vehicle collision as the leading cause of …

Carfentanil is a synthetic fentanyl analogue approved for veterinary use. It is a mu-opioid
receptor agonist with an estimated analgesic potency approximately 10,000 times that of …

The opioid system plays a crucial role in the neural modulation of anxiety. The involvement
of opioid ligands and receptors in physiological and dysfunctional forms of anxiety is …

Deep brain stimulation (DBS) of the periaqueductal gray (PAG) is used in the treatment of
severe refractory neuropathic pain. We tested the hypothesis that DBS releases …

The continuous rise in opioid overdoses in the United States is predominantly driven by very
potent synthetic opioids, mostly fentanyl and its derivatives (fentanyls). Although naloxone …

Schizophrenia is a debilitating mental illness that affects approximately 1% of the world's
population. Despite much research in its neurobiology to aid in developing new treatments …

What percentage of receptors, ion channels or transporters must be occupied by drugs to
trigger therapeutic effects in patients, or by drugs and other ligands to induce physiological …