The neurovascular unit (NVU) is a complex multi-cellular structure consisting of endothelial
cells (ECs), neurons, glia, smooth muscle cells (SMCs), and pericytes. Each component is …

The Blood Brain Barrier (BBB) is a specialized vascular structure tightly regulating central
nervous system (CNS) homeostasis. Endothelial cells are the central component of the BBB …

A precise communication between the nervous and the vascular systems is crucial for
proper formation and function of the central nervous system (CNS). Interestingly, this …

Background Schizophrenia, a relatively common psychiatric syndrome, affects virtually all
brain functions yet has eluded explanation for more than 100 years. Whether by …

As clinicians attempt to understand the underlying reasons for the vulnerability of different
regions of the developing brain to injury, it is apparent that little is known as to how hypoxia …

In order to better understand the process of angiogenesis in the developing human brain,
we have examined the spatial relationship and relative contributions of endothelial cells and …

Cerebrovascular lesions, mainly germinal matrix hemorrhage and ischemic injury to the
periventricular white matter, are major causes of adverse neurodevelopmental outcome in …

The germinal matrix of premature infants is selectively vulnerable to hemorrhage within the
first 48 h of life. To assess the role of vascular immaturity in germinal matrix hemorrhage …

Schizophrenia (SZ) is a severe mental disorder with unknown etiology and elusive
neuropathological and neurobiological features have been a focus of many theoretical …

Central nervous system diseases involving the parenchymal microvessels are frequently
associated with a 'microvasculopathy', which includes different levels of neurovascular unit …