Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis

ZM Manjaly, NA Harrison, HD Critchley… - Journal of Neurology …, 2019 - jnnp.bmj.com
Fatigue is one of the most common symptoms in multiple sclerosis (MS), with a major impact
on patients' quality of life. Currently, treatment proceeds by trial and error with limited …

The thalamus and multiple sclerosis: modern views on pathologic, imaging, and clinical aspects

A Minagar, MH Barnett, RHB Benedict, D Pelletier… - Neurology, 2013 - AAN Enterprises
The paired thalamic nuclei are gray matter (GM) structures on both sides of the third ventricle
that play major roles in cortical activation, relaying sensory information to the higher cortical …

Structural brain changes in patients with post-COVID fatigue: a prospective observational study

J Heine, K Schwichtenberg, TJ Hartung, S Rekers… - …, 2023 - thelancet.com
Background Post-COVID syndrome is a severe long-term complication of COVID-19.
Although fatigue and cognitive complaints are the most prominent symptoms, it is unclear …

Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron

L Haider, C Simeonidou, G Steinberger… - Journal of Neurology …, 2014 - jnnp.bmj.com
In multiple sclerosis (MS), diffuse degenerative processes in the deep grey matter have
been associated with clinical disabilities. We performed a systematic study in MS deep grey …

Fatigue in multiple sclerosis–insights into evaluation and management

SS Ayache, MA Chalah - Neurophysiologie Clinique/Clinical …, 2017 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the
central nervous system, characterized by the accumulation of numerous neurological …

Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses

G Morris, M Berk, K Walder, M Maes - BMC medicine, 2015 - Springer
Background The genesis of severe fatigue and disability in people following acute pathogen
invasion involves the activation of Toll-like receptors followed by the upregulation of …

Altered basal ganglia functional connectivity in multiple sclerosis patients with fatigue

C Finke, J Schlichting, S Papazoglou… - Multiple Sclerosis …, 2015 - journals.sagepub.com
Background: Fatigue is one of the most frequent and disabling symptoms in multiple
sclerosis, but its pathophysiological mechanisms are poorly understood. It is in particular …

Role of inflammation in human fatigue: relevance of multidimensional assessments and potential neuronal mechanisms

B Karshikoff, T Sundelin, J Lasselin - Frontiers in immunology, 2017 - frontiersin.org
Fatigue is a highly disabling symptom in various medical conditions. While inflammation has
been suggested as a potential contributor to the development of fatigue, underlying …

Multiple sclerosis and fatigue: a review on the contribution of inflammation and immune-mediated neurodegeneration

R Patejdl, IK Penner, TK Noack, UK Zettl - Autoimmunity reviews, 2016 - Elsevier
Multiple sclerosis (MS) is an immune mediated disease of the central nervous system (CNS)
and the leading cause of non-traumatic disability among young and middle-aged adults in …

Role of oligodendrocyte dysfunction in demyelination, remyelination and neurodegeneration in multiple sclerosis

AO Dulamea - Multiple Sclerosis: Bench to Bedside: Global …, 2017 - Springer
Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS) during
development and throughout adulthood. They result from a complex and well controlled …