Anthracyclines: biosynthesis, engineering and clinical applications
MB Hulst, T Grocholski, JJC Neefjes… - Natural Product …, 2022 - pubs.rsc.org
Covering: January 1995 to June 2021 Anthracyclines are glycosylated microbial natural
products that harbour potent antiproliferative activities. Doxorubicin has been widely used as …
products that harbour potent antiproliferative activities. Doxorubicin has been widely used as …
Taxonomy, physiology, and natural products of Actinobacteria
EA Barka, P Vatsa, L Sanchez… - Microbiology and …, 2016 - Am Soc Microbiol
Actinobacteria are Gram-positive bacteria with high G+ C DNA content that constitute one of
the largest bacterial phyla, and they are ubiquitously distributed in both aquatic and …
the largest bacterial phyla, and they are ubiquitously distributed in both aquatic and …
The regulation of the secondary metabolism of Streptomyces: new links and experimental advances
GP Van Wezel, KJ McDowall - Natural product reports, 2011 - pubs.rsc.org
Covering: up to early 2011 Streptomycetes and other actinobacteria are renowned as a rich
source of natural products of clinical, agricultural and biotechnological value. They are being …
source of natural products of clinical, agricultural and biotechnological value. They are being …
Chemistry and biology of roseophilin and the prodigiosin alkaloids: a survey of the last 2500 years
A Fürstner - Angewandte Chemie International Edition, 2003 - Wiley Online Library
The pyrrole alkaloids of the prodigiosin family make up an unusual chapter in the chemistry
of natural products. Owing to the characteristic red color of these secondary metabolites …
of natural products. Owing to the characteristic red color of these secondary metabolites …
The biosynthesis and regulation of bacterial prodiginines
NR Williamson, PC Fineran, FJ Leeper… - Nature Reviews …, 2006 - nature.com
The red-pigmented prodiginines are bioactive secondary metabolites produced by both
Gram-negative and Gram-positive bacteria. Recently, these tripyrrole molecules have …
Gram-negative and Gram-positive bacteria. Recently, these tripyrrole molecules have …
Green fluorescent protein as a reporter for spatial and temporal gene expression in Streptomyces coelicolor A3(2)
J Sun, GH Kelemen, JM Fernández-Abalos… - …, 1999 - microbiologyresearch.org
The enhanced green fluorescent protein (EGFP) gene is a modified version of the green
fluorescent protein gene of the jellyfish Aequorea victoria with a codon usage that …
fluorescent protein gene of the jellyfish Aequorea victoria with a codon usage that …
Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: an unfinished story
JF Martín - Journal of bacteriology, 2004 - Am Soc Microbiol
The biosynthesis of many different types of antibiotics and other secondary metabolites is
regulated by phosphate. Production of these valuable compounds occurs only under …
regulated by phosphate. Production of these valuable compounds occurs only under …
[HTML][HTML] Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3 (2): new mechanisms for chain initiation and termination in modular …
AM Cerdeño, MJ Bibb, GL Challis - Chemistry & biology, 2001 - cell.com
Background: Prodiginines are a large family of pigmented oligopyrrole antibiotics with
medicinal potential as immunosuppressants and antitumour agents that are produced by …
medicinal potential as immunosuppressants and antitumour agents that are produced by …
A complex role for the γ‐butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2)
E Takano, R Chakraburtty, T Nihira… - Molecular …, 2001 - Wiley Online Library
Many streptomycetes produce extracellular γ‐butyrolactones. In several cases, these have
been shown to act as signals for the onset of antibiotic production. Synthesis of these …
been shown to act as signals for the onset of antibiotic production. Synthesis of these …
afsR is a pleiotropic but conditionally required regulatory gene for antibiotic production in Streptomyces coelicolor A3(2)
B Floriano, M Bibb - Molecular microbiology, 1996 - Wiley Online Library
The N‐terminal region of AfsR, a putative pleiotropic regulatory protein for antibiotic
production in Strepto‐myces coelicolor A3 (2), is homologous to RedD and ActII‐ORF4 …
production in Strepto‐myces coelicolor A3 (2), is homologous to RedD and ActII‐ORF4 …