Simple Summary Anoikis is a programmed cell death process resulting from the loss of
interaction between cells and the extracellular matrix. Therefore, it is necessary to overcome …

Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several
cardiac conditions and more recently have been recognized as potential antitumor …

Carbohydrates are abundant naturally occurring biomolecules that play essential roles in a
wide variety of biological processes. In this paper, we describe the synthesis of a series of …

Cardiac glycosides (CGs) are approved for the treatment of cardiovascular alterations and
their known cellular target is the alpha subunit of the sodium (Na+)/potassium (K+)-ATPase …

Natural compounds are the fundament of pharmacological treatments and more than 50% of
all anticancer drugs are of natural origins or at least derived from scaffolds present in Nature …

Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as
a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon …

Cancer stem cells (CSCs) have been reported as a major cause of cancer metastasis and
the failure of cancer treatment. Cumulative studies have indicated that protein kinase B (Akt) …

Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-
cancer activities. Despite their well-established target, the sodium/potassium (Na+/K+) …

Cardiac glycosides (CGs) are natural compounds used traditionally to treat congestive heart
diseases. Recent investigations repositioned CGs as potential anticancer agents. To …

Background Acute myeloid leukemia (AML) is an aggressive hematologic malignancy
characterized by an accumulation of immature leukemic myeloblasts initiating from leukemic …