Background The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin),
receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1 …

The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs)
were originally characterized as passive reservoirs of circulating IGFs, but they are now …

Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), one of the six members of the
IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an IGF-dependent …

The 6 high-affinity insulin-like growth factor binding proteins (IGFBPs) are multifunctional
proteins that modulate cell signaling through multiple pathways. Their canonical function at …

Lipid abnormalities are among the key risk factors for cardiovascular disease. Indeed, lipid-
modifying drugs—in particular, the statins, which primarily lower plasma levels of low …

The IGF system plays critical roles in somatic growth in an endocrine fashion (somatomedin
hypothesis) as well as proliferation and differentiation of normal and malignant cells in a …

Reactive oxygen species (ROS) modulate sphingolipid metabolism, including enzymes that
generate ceramide and sphingosine-1-phosphate (S1P), and a ROS-antioxidant rheostat …

The insulin-like growth factor (IGF) system plays essential role in the regulation of cell
growth, proliferation and survival and affects nearly every organ system in the body. IGF-I …

Among its pleiotropic actions, ghrelin modulates insulin secretion and glucose metabolism.
Herein we investigated the role of ghrelin in pancreatic β-cell proliferation and apoptosis …

The sphingolipid ceramide induces macroautophagy (here called autophagy) and cell death
with autophagic features in cancer cells. Here we show that overexpression of sphingosine …