Connexins are assembled into dodecamer intercellular channels, a collection of which is
termed a gap junction, and their canonical function allowing direct exchange of ions and …

The 'cancer stem cell'hypothesis has pointed to a specific target for new cancer therapies.
The hypothesis is based on the observation that only the 'cancer stem cell'among the other …

Missense mutations in the p53 tumor suppressor abound in human cancer. Common
(“hotspot”) mutations endow mutant p53 (mutp53) proteins with oncogenic gain of function …

Simple Summary Connexins are proteins which comprise gap junctions in cells. These
junctions can directly connect neighboring cells and the cell interior with the extracellular …

Connexins are a family of transmembrane proteins that regulate diverse cellular functions.
Originally characterized for their ability to mediate direct intercellular communication through …

Simple Summary Electric potential patterns across tissues are instructive for development,
regeneration, and tumorigenesis because they can influence transcription, migration, and …

Acyl-coenzyme A synthetase medium chain family member 1 (ACSM1) is a medium chain
Acyl-CoA Synthetase family member and plays an important role in fatty acid metabolism …

Dysregulation of gap junction intercellular communication (GJIC) is recognized as one of the
key hallmarks for identifying non-genotoxic carcinogens (NGTxC). Currently, there is a …

From the moment a cell is on the path to malignant transformation, its interaction with other
cells from the microenvironment becomes altered. The flow of molecular information is at the …

Necroptosis is an alternative form of programmed cell death that generally occurs under
apoptosis‐deficient conditions. Our previous work showed that connexin32 (Cx32) promotes …