Cannabinoids, endocannabinoids, and synthetic cannabimimetic molecules in neuromuscular disorders

FA Iannotti - International Journal of Molecular Sciences, 2023 - mdpi.com
Neuromuscular disorders (NMDs) encompass a large heterogeneous group of hereditary
and acquired diseases primarily affecting motor neurons, peripheral nerves, and the skeletal …

The emerging role of the endocannabinoidome-gut microbiome axis in eating disorders

HD Mir, G Giorgini, V Di Marzo - Psychoneuroendocrinology, 2023 - Elsevier
Among the sources of chemical signals regulating food intake, energy metabolism and body
weight, few have attracted recently as much attention as the expanded endocannabinoid …

When dysbiosis meets dystrophy: an unwanted gut‐muscle connection

A Jayaraman, S Pettersson - EMBO molecular medicine, 2023 - embopress.org
Duchenne muscular dystrophy (DMD) is a devastating neuromuscular degenerative disease
with no known cure to date. In recent years, the hypothesis of a “gut‐muscle axis” has …

Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin

H Kalkan, E Panza, E Pagano, G Ercolano… - Cell Death & …, 2023 - nature.com
Statins are the most prescribed lipid-lowering agents worldwide. Their use is generally safe,
although muscular toxicity occurs in about 1 in 10.000 patients. In this study, we explored the …

Mitochondria and Reactive Oxygen Species: The Therapeutic Balance of Powers for Duchenne Muscular Dystrophy

SR Casati, D Cervia, P Roux-Biejat, C Moscheni… - Cells, 2024 - mdpi.com
Duchenne muscular dystrophy (DMD) is a genetic progressive muscle-wasting disorder that
leads to rapid loss of mobility and premature death. The absence of functional dystrophin in …

Polyamines and physical activity in musculoskeletal diseases: A potential therapeutic challenge

L Galasso, A Cappella, A Mulè, L Castelli… - International Journal of …, 2023 - mdpi.com
Autophagy dysregulation is commonplace in the pathogenesis of several invalidating
diseases, such as musculoskeletal diseases. Polyamines, as spermidine and spermine, are …

The metabolomic plasma profile of patients with Duchenne muscular dystrophy: Providing new evidence for its pathogenesis

H Xu, X Cai, K Xu, Q Wu, B Xu - Orphanet Journal of Rare Diseases, 2023 - Springer
Background Duchenne muscular dystrophy (DMD) is a fatal genetic muscle-wasting disease
that affects 1 in 5000 male births with no current cure. Despite great progress has been …

Advancing Biomarker Discovery and Therapeutic Targets in Duchenne Muscular Dystrophy: A Comprehensive Review

M Molinaro, Y Torrente, C Villa, A Farini - International Journal of …, 2024 - mdpi.com
Mounting evidence underscores the intricate interplay between the immune system and
skeletal muscles in Duchenne muscular dystrophy (DMD), as well as during regular muscle …

Impact of gut microbiota on the peripheral nervous system in physiological, regenerative and pathological conditions

S Calabrò, S Kankowski, M Cescon… - International Journal of …, 2023 - mdpi.com
It has been widely demonstrated that the gut microbiota is responsible for essential functions
in human health and that its perturbation is implicated in the development and progression …

Dynamic changes in butyrate levels regulate satellite cell homeostasis by preventing spontaneous activation during aging

S Chen, L Huang, B Liu, H Duan, Z Li, Y Liu… - Science China Life …, 2024 - Springer
The gut microbiota plays a pivotal role in systemic metabolic processes and in particular
functions, such as developing and preserving the skeletal muscle system. However, the …