Small nucleolar RNAs (snoRNAs), a type of non-coding RNA, are widely present in the
nucleoli of eukaryotic cells and play an important role in rRNA modification. With the recent …

Abstract Box C/D and H/ACA RNPs are essential ribonucleoprotein particles that are found
throughout both eukaryotes [small nucleolar RNPs (snoRNPs)] and archaea [snoRNP‐like …

Many neurogenetic disorders are caused by the mutation of ubiquitously expressed genes.
One such disorder, spinal muscular atrophy, is caused by loss or mutation of the survival …

Recent advances have fuelled rapid growth in our appreciation of the tremendous number,
diversity and biological importance of non-coding (nc) RNAs. Because ncRNAs typically …

Several proto-oncogenes and tumor suppressors regulate the production of ribosomes.
Ribosome biogenesis is a major consumer of cellular energy, and defects result in p53 …

Box C/D and box H/ACA snoRNAs are abundant non-coding RNAs that localize in the
nucleolus and mostly function as guides for nucleotide modifications. While a large pool of …

Nucleoli are the prominent contrasted structures of the cell nucleus. In the nucleolus,
ribosomal RNAs are synthesized, processed and assembled with ribosomal proteins. RNA …

Eukaryotes and archaea use two sets of specialized ribonucleoproteins (RNPs) to carry out
sequence-specific methylation and pseudouridylation of RNA, the two most abundant types …

Telomerase is a multisubunit ribonucleoprotein (RNP) complex that adds telomere repeats
to the ends of chromosomes. Three essential telomerase components have been identified …

Hyperactive ribosomal biogenesis is widely observed in cancer, which has been partly
attributed to the increased rDNA transcription by Pol I in cancer. However, whether small …