The evolution of natural killer cell receptors
Natural killer (NK) cells are immune cells that play a crucial role against viral infections and
tumors. To be tolerant against healthy tissue and simultaneously attack infected cells, the …
tumors. To be tolerant against healthy tissue and simultaneously attack infected cells, the …
Human KIR repertoires: shaped by genetic diversity and evolution
AR Manser, S Weinhold, M Uhrberg - Immunological reviews, 2015 - Wiley Online Library
Killer cell immunoglobulin‐like receptors (KIR s) on natural killer (NK) cells are crucially
involved in the control of cancer development and virus infection by probing cells for proper …
involved in the control of cancer development and virus infection by probing cells for proper …
Co‐evolution of MHC class I and variable NK cell receptors in placental mammals
Shaping natural killer (NK) cell functions in human immunity and reproduction are diverse
killer cell immunoglobulin‐like receptors (KIR s) that recognize polymorphic MHC class I …
killer cell immunoglobulin‐like receptors (KIR s) that recognize polymorphic MHC class I …
Two to tango: co-evolution of hominid natural killer cell receptors and MHC
EE Wroblewski, P Parham, LA Guethlein - Frontiers in immunology, 2019 - frontiersin.org
Natural killer (NK) cells have diverse roles in hominid immunity and reproduction.
Modulating these functions are the interactions between major histocompatibility complex …
Modulating these functions are the interactions between major histocompatibility complex …
Co‐evolution of the MHC class I and KIR gene families in rhesus macaques: ancestry and plasticity
NG de Groot, JH Blokhuis, N Otting… - Immunological …, 2015 - Wiley Online Library
Researchers dealing with the human leukocyte antigen (HLA) class I and killer
immunoglobulin receptor (KIR) multi‐gene families in humans are often wary of the complex …
immunoglobulin receptor (KIR) multi‐gene families in humans are often wary of the complex …
Conservation, extensive heterozygosity, and convergence of signaling potential all indicate a critical role for KIR3DL3 in higher primates
Natural killer (NK) cell functions are modulated by polymorphic killer cell immunoglobulin-
like receptors (KIR). Among 13 human KIR genes, which vary by presence and copy …
like receptors (KIR). Among 13 human KIR genes, which vary by presence and copy …
Diversification of both KIR and NKG2 natural killer cell receptor genes in macaques – implications for highly complex MHC‐dependent regulation of natural killer …
L Walter, B Petersen - Immunology, 2017 - Wiley Online Library
The killer immunoglobulin‐like receptors (KIR) as well as their MHC class I ligands display
enormous genetic diversity and polymorphism in macaque species. Signals resulting from …
enormous genetic diversity and polymorphism in macaque species. Signals resulting from …
Rhesus Macaque Killer Cell Ig-like Receptor Domain 0 Glycans Impact Surface Expression and Ligand Specificity
JL Anderson, K Sandstrom, VA Klenchin… - The Journal of …, 2024 - journals.aai.org
Defining the MHC class I ligands of rhesus macaque killer cell Ig-like receptors (KIRs) is
fundamental to NK cell biology in this species as a model for infectious diseases and …
fundamental to NK cell biology in this species as a model for infectious diseases and …
Monkeying around: using non-human primate models to study NK cell biology in HIV infections
C Manickam, SV Shah, J Nohara, G Ferrari… - Frontiers in …, 2019 - frontiersin.org
Natural killer (NK) cells are the major innate effectors primed to eliminate virus-infected and
tumor or neoplastic cells. Recent studies also suggest nuances in phenotypic and functional …
tumor or neoplastic cells. Recent studies also suggest nuances in phenotypic and functional …
HLA/MHC and KIR characterization in humans and non‐human primates using Oxford Nanopore Technologies and Pacific Biosciences sequencing platforms
J Bruijnesteijn - Hla, 2023 - Wiley Online Library
The gene products of the HLA/MHC and KIR multigene families are important modulators of
the immune system and are associated with health and disease. Characterization of the …
the immune system and are associated with health and disease. Characterization of the …