NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps
JM Adrover, SAC McDowell, XY He, DF Quail… - Cancer Cell, 2023 - cell.com
Neutrophils are major effectors and regulators of the immune system. They play critical roles
not only in the eradication of pathogens but also in cancer initiation and progression …
not only in the eradication of pathogens but also in cancer initiation and progression …
Neutrophil intrinsic and extrinsic regulation of NETosis in health and disease
Neutrophil extracellular traps (NETs) evolved to protect the host against microbial infections
and are formed by a web-like structure of DNA that is decorated with antimicrobial effectors …
and are formed by a web-like structure of DNA that is decorated with antimicrobial effectors …
IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer
N Caronni, F La Terza, FM Vittoria, G Barbiera… - Nature, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to
therapies. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …
therapies. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …
Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
A Garrido-Trigo, AM Corraliza, M Veny, I Dotti… - Nature …, 2023 - nature.com
Ulcerative colitis and Crohn's disease are chronic inflammatory intestinal diseases with
perplexing heterogeneity in disease manifestation and response to treatment. While the …
perplexing heterogeneity in disease manifestation and response to treatment. While the …
Strategies of neutrophil diversification
M Palomino-Segura, J Sicilia, I Ballesteros… - Nature …, 2023 - nature.com
Neutrophils are formidable defenders. Their vast numbers, constant production, high
cytotoxicity and capacity to produce extracellular traps, underlie their ability to efficiently …
cytotoxicity and capacity to produce extracellular traps, underlie their ability to efficiently …
Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis
Neutrophils, the most abundant innate immune cells, function as crucial regulators of the
adaptive immune system in diverse pathological conditions, including metastatic cancer …
adaptive immune system in diverse pathological conditions, including metastatic cancer …
Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections
Critically ill patients in intensive care units experience profound alterations of their gut
microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections …
microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections …
Deterministic reprogramming of neutrophils within tumors
Neutrophils are increasingly recognized as key players in the tumor immune response and
are associated with poor clinical outcomes. Despite recent advances characterizing the …
are associated with poor clinical outcomes. Despite recent advances characterizing the …
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology
GS Gullotta, D De Feo, E Friebel, A Semerano… - Nature …, 2023 - nature.com
Aging accounts for increased risk and dismal outcome of ischemic stroke. Here, we
investigated the impact of age-related changes in the immune system on stroke. Upon …
investigated the impact of age-related changes in the immune system on stroke. Upon …
Neutrophils in physiology and pathology
A Aroca-Crevillén, T Vicanolo, S Ovadia… - Annual Review of …, 2024 - annualreviews.org
Infections, cardiovascular disease, and cancer are major causes of disease and death
worldwide. Neutrophils are inescapably associated with each of these health concerns, by …
worldwide. Neutrophils are inescapably associated with each of these health concerns, by …