Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder
MH Cho, BD Hobbs, EK Silverman - The Lancet Respiratory …, 2022 - thelancet.com
Chronic obstructive pulmonary disease (COPD) is a deadly and highly morbid disease.
Susceptibility to and heterogeneity of COPD are incompletely explained by environmental …
Susceptibility to and heterogeneity of COPD are incompletely explained by environmental …
[HTML][HTML] Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke
M Hikichi, K Mizumura, S Maruoka… - Journal of thoracic …, 2019 - ncbi.nlm.nih.gov
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease that is
characterized by functional and structural alterations primarily caused by long-term …
characterized by functional and structural alterations primarily caused by long-term …
An integrated cell atlas of the lung in health and disease
Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions …
typically capture only a limited number of donors and disagree on cell type definitions …
[HTML][HTML] A single-cell atlas of chromatin accessibility in the human genome
Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …
Association of clonal hematopoiesis with chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but
other determinants of the disease are incompletely understood. Clonal hematopoiesis of …
other determinants of the disease are incompletely understood. Clonal hematopoiesis of …
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
Characterization of the COPD alveolar niche using single-cell RNA sequencing
Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide,
however our understanding of cell specific mechanisms underlying COPD pathobiology …
however our understanding of cell specific mechanisms underlying COPD pathobiology …
Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models
Chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide,
is highly heritable. While COPD is clinically defined by applying thresholds to summary …
is highly heritable. While COPD is clinically defined by applying thresholds to summary …
Syndrome of combined pulmonary fibrosis and emphysema: an official ATS/ERS/JRS/ALAT research statement
Background: The presence of emphysema is relatively common in patients with fibrotic
interstitial lung disease. This has been designated combined pulmonary fibrosis and …
interstitial lung disease. This has been designated combined pulmonary fibrosis and …
Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial
Background Genetic data implicate IL-33 in asthma susceptibility. Itepekimab, a monoclonal
antibody targeting IL-33, demonstrated clinical activity in asthma, with potential in chronic …
antibody targeting IL-33, demonstrated clinical activity in asthma, with potential in chronic …