Organometallic anticancer compounds

G Gasser, I Ott, N Metzler-Nolte - Journal of medicinal chemistry, 2011 - ACS Publications
The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …

Organometallic and coordination rhenium compounds and their potential in cancer therapy

EB Bauer, AA Haase, RM Reich, DC Crans… - Coordination Chemistry …, 2019 - Elsevier
This review focuses on cytotoxic rhenium compounds in terms of IC 50 values, their mode of
action in biological systems and their status in clinical trials. Biological studies of different …

Underestimated potential of organometallic rhenium complexes as anticancer agents

A Leonidova, G Gasser - ACS chemical biology, 2014 - ACS Publications
In the recent years, organometallic compounds have become recognized as promising anti-
cancer drug candidates. While radioactive 186/188Re compounds are already used in …

Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes

YK Yan, M Melchart, A Habtemariam… - Chemical …, 2005 - pubs.rsc.org
Our work has shown that certain ruthenium (II) arene complexes exhibit promising
anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their …

Towards cancer cell-specific phototoxic organometallic rhenium (I) complexes

A Leonidova, V Pierroz, R Rubbiani, J Heier… - Dalton …, 2014 - pubs.rsc.org
Over the recent years, several Re (I) organometallic compounds have been shown to be
toxic to various cancer cell lines. However, these compounds lacked sufficient selectivity …

Identification of novel potent and non-toxic anticancer, anti-angiogenic and antimetastatic rhenium complexes against colorectal carcinoma

J Delasoie, A Pavic, N Voutier, S Vojnovic… - European journal of …, 2020 - Elsevier
Combination therapy targeting both tumor growth and vascularization is considered to be a
cornerstone for colorectal carcinomas (CRC) treatment. However, the major obstacles of …

Necroptosis-inducing rhenium (V) oxo complexes

K Suntharalingam, SG Awuah, PM Bruno… - Journal of the …, 2015 - ACS Publications
Rhenium (V) oxo complexes of general formula [ReO (OMe)(N^ N) Cl2], where N^ N= 4, 7-
diphenyl-1, 10-phenanthroline, 1, or 3, 4, 7, 8-tetramethyl-1, 10-phenanthroline, 2, effectively …

Therapeutic and diagnostic applications of multimetallic rhenium (I) tricarbonyl complexes

Z Huang, JJ Wilson - European Journal of Inorganic Chemistry, 2021 - Wiley Online Library
By virtue of their favorable properties, rhenium (I) tricarbonyl (Re (CO) 3) complexes have
arisen as novel therapeutic agents and cellular imaging probes for addressing problems of …

Targeting the Folate Receptor (FR): Imaging and Cytotoxicity of ReI Conjugates in FR‐Overexpressing Cancer Cells

N Viola‐Villegas, AE Rabideau… - ChemMedChem …, 2008 - Wiley Online Library
The synthesis, characterization, in vitro imaging, and cytotoxic properties of a new folate
conjugate of rhenium (I) are reported. The conjugate [FA‐PEG‐BQAV‐Re (CO) 3]+(γ‐4) was …

A Deadly Organometallic Luminescent Probe: Anticancer Activity of a ReI Bisquinoline Complex

I Kitanovic, S Can, H Alborzinia… - … A European Journal, 2014 - Wiley Online Library
The photophysical properties of [Re (CO) 3 (l‐N3)] Br (l‐N3= 2‐azido‐N, N‐bis [(quinolin‐2‐
yl) methyl] ethanamine), which could not be localized in cancer cells by fluorescence …