Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy

Q Lin, S Li, N Jiang, H Jin, X Shao, X Zhu, J Wu… - Autophagy, 2021 - Taylor & Francis
The pathogenetic mechanism of contrast-induced acute kidney injury (CI-AKI), which is the
third most common cause of hospital-acquired AKI, has not been elucidated. Previously, we …

Targeting the redox system for cardiovascular regeneration in aging

MS Allemann, P Lee, JH Beer, SS Saeedi Saravi - Aging Cell, 2023 - Wiley Online Library
Cardiovascular aging presents a formidable challenge, as the aging process can lead to
reduced cardiac function and heightened susceptibility to cardiovascular diseases …

Turning the oxygen dial: balancing the highs and lows

AH Baik, IH Jain - Trends in cell biology, 2020 - cell.com
Oxygen is both vital and toxic to life. Molecular oxygen is the most used substrate in the
human body and is required for several hundred diverse biochemical reactions. The …

[HTML][HTML] Genistein mitigates senescence of bone marrow mesenchymal stem cells via ERRα-mediated mitochondrial biogenesis and mitophagy in ovariectomized rats

M Li, Y Yu, K Xue, J Li, G Son, J Wang, W Qian… - Redox Biology, 2023 - Elsevier
Senescence of bone marrow mesenchymal stem cells (BMMSCs) induced by chronic
oxidative stress is an important factor contributes to the postmenopausal osteoporosis …

A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations

G Sturm, AS Monzel, KR Karan, J Michelson, SA Ware… - Scientific Data, 2022 - nature.com
Aging is a process of progressive change. To develop biological models of aging,
longitudinal datasets with high temporal resolution are needed. Here we report a multi …

Cellular signaling in the hypoxic cancer microenvironment: Implications for drug resistance and therapeutic targeting

HA Bakshi, M Mkhael, HL Faruck, AU Khan… - Cellular …, 2024 - Elsevier
The rewiring of cellular metabolism is a defining characteristic of cancer, as tumor cells
adapt to acquire essential nutrients from a nutrient-poor environment to sustain their viability …

The Mito-Hormetic mechanisms of ozone in the clearance of SARS-CoV2 and in the COVID-19 therapy

S Chirumbolo, A Varesi, M Franzini, L Valdenassi… - Biomedicines, 2022 - mdpi.com
An increasing body of evidence in the literature is reporting the feasibility of using medical
ozone as a possible alternative and adjuvant treatment for COVID-19 patients, significantly …

Stem cell metabolism: powering cell-based therapeutics

VOC Rigaud, R Hoy, S Mohsin, M Khan - Cells, 2020 - mdpi.com
Cell-based therapeutics for cardiac repair have been extensively used during the last
decade. Preclinical studies have demonstrated the effectiveness of adoptively transferred …

Epigenetic alterations under oxidative stress in stem cells

M Huang, Q Wu, ZH Jiang - Oxidative Medicine and Cellular …, 2022 - Wiley Online Library
Epigenetic regulation of gene expression, including DNA methylation and histone
modifications, provides finely tuned responses for cells that undergo cellular environment …

Enhancing myocardial repair with CardioClusters

MM Monsanto, BJ Wang, ZR Ehrenberg… - Nature …, 2020 - nature.com
Cellular therapy to treat heart failure is an ongoing focus of intense research, but progress
toward structural and functional recovery remains modest. Engineered augmentation of …