Per-ARNT-Sim (PAS) domains serve as versatile sensor and interaction modules in signal
transduction proteins. PAS sensors detect chemical and physical stimuli and regulate the …

From cyanobacteria to mammals, organisms have evolved timing mechanisms to adapt to
environmental changes in order to optimize survival and improve fitness. To anticipate these …

Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated
with metabolic disease and reduced levels of NAD+, yet whether changes in nucleotide …

This is the second set of Handbook of Porphyrin Science. Porphyrins, phthalocyanines and
their numerous analogues and derivatives are materials of tremendous importance in …

The circadian clock in mammals is driven by an autoregulatory transcriptional feedback
mechanism that takes approximately 24 hours to complete. A key component of this …

Phytochromes are red/far-red light photoreceptors that direct photosensory responses
across the bacterial, fungal and plant kingdoms. These include photosynthetic potential and …

The Neurospora crassa photoreceptor Vivid tunes blue-light responses and modulates
gating of the circadian clock. Crystal structures of dark-state and light-state Vivid reveal a …

Direct evidence for the requirement of transcriptional feedback repression in circadian clock
function has been elusive. Here, we developed a molecular genetic screen in mammalian …

LOV (light, oxygen or voltage) domains are protein photosensors that are conserved in
bacteria, archaea, plants and fungi, and detect blue light via a flavin cofactor. LOV domains …

The hypoxia-inducible factor (HIF) basic helix–loop–helix Per-aryl hydrocarbon receptor
nuclear translocator (ARNT)-Sim (bHLH-PAS) transcription factors are master regulators of …