Perioperative organ injury is among the leading causes of morbidity and mortality of surgical
patients. Among different types of perioperative organ injury, acute kidney injury occurs …

Acute kidney injury (AKI) complicates recovery from cardiac surgery in up to 30% of patients,
injures and impairs the function of the brain, lungs, and gut, and places patients at a 5-fold …

Methods ADQI (Acute Disease Quality Initiative) is an ongoing process that produces
evidence‐based recommendations on the diagnosis, prevention, and management of AKI …

Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Isoprostanes (IsoPs) are prostaglandin-like molecules generated independent of the
cyclooxygenase (COX) by the free radical-induced peroxidation of arachidonic acid. The first …

Acute kidney injury (AKI), previously termed acute renal failure, is associated with increased
mortality, prolonged hospital stay, and accelerated chronic kidney disease (CKD). Over the …

The incidence of perioperative acute kidney injury (AKI) is more common than previously
recognized, especially in high-risk patients undergoing higher risk procedures. The growing …

Importance Statins affect several mechanisms underlying acute kidney injury (AKI).
Objective To test the hypothesis that short-term high-dose perioperative atorvastatin would …

Inflammation has an integral role in the pathophysiology of AKI. We investigated the
associations of two biomarkers of inflammation, plasma IL-6 and IL-10, with AKI and …

Objectives: Although obesity is associated with risk for chronic kidney disease and improved
survival, less is known about the associations of obesity with risk of acute kidney injury and …