The continuous degradation and synthesis of prokaryotic mRNAs not only give rise to the
metabolic changes that are required as cells grow and divide but also rapid adaptation to …

Poly (A) tails have long been known as stable 3′ modifications of eukaryotic mRNAs,
added during nuclear pre‐mRNA processing. It is now appreciated that this modification is …

Much of the information available about factors that affect mRNA decay in Escherichia coli,
and by inference in other bacteria, has been gleaned from study of less than 25 of the≈ …

Eukaryotic cells contain several unconventional poly (A) polymerases in addition to the
canonical enzymes responsible for the synthesis of poly (A) tails of nuclear messenger RNA …

THE leucine-rich repeat is a recently characterized structural motif1 used in molecular
recognition processes as diverse as signal transduction, cell adhesion, cell development …

mRNA degradation is an important mechanism for controlling gene expression in bacterial
cells. This process involves the orderly action of a battery of cellular endonucleases and …

1Department of Biochemistry and Molecular Biology, Pennsylvania State University College
of Medicine, Hershey, Pennsylvania 17033, USA; 2Department of Biochemistry and …

In Escherichia coli, the global regulatory protein CsrA (carbon store regulator A) binds to
leader segments of target mRNAs, affecting their translation and stability. CsrA activity is …

RNA snap™ is a simple and novel method that recovers all intracellular RNA quantitatively
(> 99%), faster (< 15 min) and less expensively (∼ 3 cents/sample) than any of the currently …

In vitro, polynucleotide phosphorylase of Escherichia coli can both synthesize RNA by using
nucleotide diphosphates as precursors and exonucleolytically degrade RNA in the presence …