Nonalcoholic fatty liver disease (NAFLD) includes a spectrum of liver disorders, from fatty
liver to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma …

Cirrhosis is a severe form of liver fibrosis that results in the irreversible replacement of liver
tissue with scar tissue in the liver. Environmental toxicity, infections, metabolic causes, or …

Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH)
pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH …

Objective Systemic immune-inflammation index (SII), a novel inflammatory indicator based
on platelets, neutrophils and lymphocytes, has been shown to be associated with prognostic …

Objective The current treatment for hepatocellular carcinoma (HCC) to block angiogenesis
and immunosuppression provides some benefits only for a subset of patients with HCC, thus …

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease
worldwide. Despite extensive research and multiple clinical trials, there are still no FDA …

Complications of the liver are amongst the world's worst diseases. Liver fibrosis is the first
stage of liver problems, while cirrhosis is the last stage, which can lead to death. The …

Chronic liver injury induces the activation of hepatic stellate cells (HSCs) into myofibroblasts,
which produce excessive amounts of extracellular matrix (ECM), resulting in tissue fibrosis. If …

Liver diseases, such as viral hepatitis, alcoholic hepatitis and cirrhosis, nonalcoholic
steatohepatitis, and hepatocellular carcinoma place a heavy burden on many patients …

The hedgehog (Hh) signaling pathway is an evolutionarily conserved pathway that regulates
embryonic development in vertebrates. However, strong evidence suggests the role of its …